Regulation of cell cycle progression and gene expression by H2A deubiquitination

Heui-Yun Joo, Ling Zhai, Chunying Yang, Shuyi Nie, Hediye Erdjument-Bromage, Paul Tempst, Chenbei Chang and Hengbin Wang ()
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Heui-Yun Joo: University of Alabama at Birmingham, Kaul Human Genetics Building 402A, 720 South 20th Street, Birmingham, Alabama 35294, USA
Ling Zhai: University of Alabama at Birmingham, Kaul Human Genetics Building 402A, 720 South 20th Street, Birmingham, Alabama 35294, USA
Chunying Yang: University of Alabama at Birmingham, Kaul Human Genetics Building 402A, 720 South 20th Street, Birmingham, Alabama 35294, USA
Shuyi Nie: University of Alabama at Birmingham, MCLM 360, Birmingham, Alabama 35294-0005, USA
Hediye Erdjument-Bromage: Molecular Biology Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, New York 10021, USA
Paul Tempst: Molecular Biology Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, New York 10021, USA
Chenbei Chang: University of Alabama at Birmingham, MCLM 360, Birmingham, Alabama 35294-0005, USA
Hengbin Wang: University of Alabama at Birmingham, Kaul Human Genetics Building 402A, 720 South 20th Street, Birmingham, Alabama 35294, USA

Nature, 2007, vol. 449, issue 7165, 1068-1072

Abstract: An enzyme, Ubp-M, is identified that removes the ubiquitin modification from histone H2A. Depletion of Ubp-M leads to slower cell growth and abnormal chromosome segregation in mitosis. In addition, depletion of Ubp-M causes defects in development and dysregulation of Hox gene expression.

Date: 2007
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DOI: 10.1038/nature06256

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