Histone demethylase JHDM2A is critical for Tnp1 and Prm1 transcription and spermatogenesis

Yuki Okada, Greg Scott, Manas K. Ray, Yuji Mishina and Yi Zhang ()
Additional contact information
Yuki Okada: Howard Hughes Medical Institute,
Greg Scott: The Knock Out Core,
Manas K. Ray: The Knock Out Core,
Yuji Mishina: The Knock Out Core,
Yi Zhang: Howard Hughes Medical Institute,

Nature, 2007, vol. 450, issue 7166, 119-123

Abstract: Fertility-linked demethylase The histone H3K9 demethylase JHDM2A was known to play a role in transcriptional activation mediated by the androgen receptor. Now targeted disruption of the Jhdm2a gene in mice shows that the enzyme is involved in spermatogenesis and regulation of transition nuclear protein and protamine genes. This work points to a role for this histone demethylase in the late stages of sperm production and maturation, and Jhdm2a becomes a possible candidate gene for infertility syndromes that have not yet been fully characterized.

Date: 2007
References: Add references at CitEc
Citations: View citations in EconPapers (1)

Downloads: (external link)
https://www.nature.com/articles/nature06236 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:450:y:2007:i:7166:d:10.1038_nature06236

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature06236

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().