Subcapsular sinus macrophages in lymph nodes clear lymph-borne viruses and present them to antiviral B cells

Tobias Junt, E. Ashley Moseman, Matteo Iannacone, Steffen Massberg, Philipp A. Lang, Marianne Boes, Katja Fink, Sarah E. Henrickson, Dmitry M. Shayakhmetov, Nelson C. Di Paolo, Nico van Rooijen, Thorsten R. Mempel, Sean P. Whelan and Ulrich H. von Andrian ()
Additional contact information
Tobias Junt: Harvard Medical School
E. Ashley Moseman: Harvard Medical School
Matteo Iannacone: Harvard Medical School
Steffen Massberg: Harvard Medical School
Philipp A. Lang: Institute of Experimental Immunology, Zurich University Hospital, Schmelzbergstrasse 12, CH-8091 Zurich, Switzerland
Marianne Boes: Brigham and Women's Hospital, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA
Katja Fink: Novartis Institute of Tropical Diseases, 10 Biopolis Road, 138670 Singapore
Sarah E. Henrickson: Harvard Medical School
Dmitry M. Shayakhmetov: University of Washington, Seattle, Washington 98195, USA
Nelson C. Di Paolo: University of Washington, Seattle, Washington 98195, USA
Nico van Rooijen: Vrije Universiteit, VUMC, Faculty of Medicine, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
Thorsten R. Mempel: Harvard Medical School
Sean P. Whelan: Harvard Medical School, 200 Longwood Avenue, Boston, Massachusetts 02115, USA
Ulrich H. von Andrian: Harvard Medical School

Nature, 2007, vol. 450, issue 7166, 110-114

Abstract: Lymph nodes help clear infecting pathogens and prevent their dissemination. In the case of lymph-borne virus, this involves a particular subpopulation of macrophages that is shown to capture the viral particles and present them to B cells, leading to B cell activation.

Date: 2007
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DOI: 10.1038/nature06287

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