Roquin represses autoimmunity by limiting inducible T-cell co-stimulator messenger RNA

Di Yu, Andy Hee-Meng Tan, Xin Hu, Vicki Athanasopoulos, Nicholas Simpson, Diego G. Silva, Andreas Hutloff, Keith M. Giles, Peter J. Leedman, Kong Peng Lam, Christopher C. Goodnow and Carola G. Vinuesa ()
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Di Yu: John Curtin School of Medical Research, The Australian National University, Canberra, 2601, Australia
Andy Hee-Meng Tan: Laboratory of Molecular and Cellular Immunology, Biomedical Sciences Institute, Agency for Science, Technology and Research (A*STAR), Singapore 138673, Singapore
Xin Hu: John Curtin School of Medical Research, The Australian National University, Canberra, 2601, Australia
Vicki Athanasopoulos: John Curtin School of Medical Research, The Australian National University, Canberra, 2601, Australia
Nicholas Simpson: John Curtin School of Medical Research, The Australian National University, Canberra, 2601, Australia
Diego G. Silva: John Curtin School of Medical Research, The Australian National University, Canberra, 2601, Australia
Andreas Hutloff: Molecular Immunology, Robert Koch-Institute, 13353, Berlin, Germany
Keith M. Giles: Laboratory for Cancer Medicine, The University of Western Australia Centre for Medical Research, Western Australian Institute for Medical Research, Perth, 6000, Australia
Peter J. Leedman: Laboratory for Cancer Medicine, The University of Western Australia Centre for Medical Research, Western Australian Institute for Medical Research, Perth, 6000, Australia
Kong Peng Lam: Laboratory of Molecular and Cellular Immunology, Biomedical Sciences Institute, Agency for Science, Technology and Research (A*STAR), Singapore 138673, Singapore
Christopher C. Goodnow: John Curtin School of Medical Research, The Australian National University, Canberra, 2601, Australia
Carola G. Vinuesa: John Curtin School of Medical Research, The Australian National University, Canberra, 2601, Australia

Nature, 2007, vol. 450, issue 7167, 299-303

Abstract: The ubiquitin ligase Roquin suppresses inducible co-stimulator Icos expression on T cells thereby protecting mice from autoimmune disease. This paper shows that it does so through regulation of Icos messenger RNA stability.

Date: 2007
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DOI: 10.1038/nature06253

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