Haemodynamics determined by a genetic programme govern asymmetric development of the aortic arch

Kenta Yashiro (), Hidetaka Shiratori and Hiroshi Hamada ()
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Kenta Yashiro: Developmental Genetics Group, Graduate School of Frontier Biosciences, Osaka University, 1–3 Yamada-oka, Suita, Osaka 565-0871, Japan
Hidetaka Shiratori: Developmental Genetics Group, Graduate School of Frontier Biosciences, Osaka University, 1–3 Yamada-oka, Suita, Osaka 565-0871, Japan
Hiroshi Hamada: Developmental Genetics Group, Graduate School of Frontier Biosciences, Osaka University, 1–3 Yamada-oka, Suita, Osaka 565-0871, Japan

Nature, 2007, vol. 450, issue 7167, 285-288

Abstract: Asymmetries of the heart In the past decade there has been remarkable progress in understanding the mechanism of left–right patterning. However, the cellular and molecular basis of asymmetric morpho-genesis remains largely unknown. Now, Yashiro et al. show that the transcription factor Pitx2 induces a dynamic morphological change in the outflow tract of the heart, which results in asymmetric blood supply to the branchial arch artery system. The uneven blood distribution results in differential signalling responses which cause the asymmetric remodelling of the great arteries.

Date: 2007
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DOI: 10.1038/nature06254

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