JHDM1B/FBXL10 is a nucleolar protein that represses transcription of ribosomal RNA genes

David Frescas, Daniele Guardavaccaro, Florian Bassermann, Ryo Koyama-Nasu and Michele Pagano ()
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David Frescas: NYU Cancer Institute, New York University School of Medicine, 550 First Avenue, New York, New York 10016, USA
Daniele Guardavaccaro: NYU Cancer Institute, New York University School of Medicine, 550 First Avenue, New York, New York 10016, USA
Florian Bassermann: NYU Cancer Institute, New York University School of Medicine, 550 First Avenue, New York, New York 10016, USA
Ryo Koyama-Nasu: NYU Cancer Institute, New York University School of Medicine, 550 First Avenue, New York, New York 10016, USA
Michele Pagano: NYU Cancer Institute, New York University School of Medicine, 550 First Avenue, New York, New York 10016, USA

Nature, 2007, vol. 450, issue 7167, 309-313

Abstract: Gene repressors Histone modifications such as lysine methylation affect chromatin structure and gene expression. Histone methylation can be reversed by the JmjC-domain family of histone demethylases. One such histone demethylase, JHDM1B, has been suggested to be a tumour suppressor. In this issue Frescas et al. confirm a probable role for JHDM1B in cancer development. JHDM1B is shown to repress expression of ribosomal RNA genes, via the demethylation of the trimethylated lysine 4 residue of histone H3. JHDM1B also influences cell growth and proliferation, suggesting that reduced levels of JHDM1B promote tumour development.

Date: 2007
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DOI: 10.1038/nature06255

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