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Maternal nodal and zebrafish embryogenesis

James T. Bennett, Heather L. Stickney, Wen-Yee Choi (), Brian Ciruna, William S. Talbot and Alexander F. Schier ()
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James T. Bennett: Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine
Heather L. Stickney: Stanford University
Wen-Yee Choi: Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine
Brian Ciruna: Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine
William S. Talbot: Stanford University
Alexander F. Schier: Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine

Nature, 2007, vol. 450, issue 7167, E1-E2

Abstract: Abstract Arising from: A. V. Gore et al. Nature 438, 1030–1035 (2005)10.1038/nature04184 ; Gore et al. reply In fish and amphibians, the dorsal axis is specified by the asymmetric localization of maternally provided components of the Wnt signalling pathway1,2. Gore et al.3 suggest that the Nodal signal Squint (Sqt) is required as a maternally provided dorsal determinant in zebrafish. Here we test their proposal and show that the maternal activities of sqt and the related Nodal gene cyclops (cyc) are not required for dorsoventral patterning.

Date: 2007
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DOI: 10.1038/nature06314

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