Gore et al. reply

Aniket V. Gore, Albert Cheong, Patrick C. Gilligan and Karuna Sampath ()
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Aniket V. Gore: Vertebrate Development Group, Temasek Life Sciences Laboratory, 1 Research Link, National University of Singapore
Albert Cheong: Vertebrate Development Group, Temasek Life Sciences Laboratory, 1 Research Link, National University of Singapore
Patrick C. Gilligan: Vertebrate Development Group, Temasek Life Sciences Laboratory, 1 Research Link, National University of Singapore
Karuna Sampath: Vertebrate Development Group, Temasek Life Sciences Laboratory, 1 Research Link, National University of Singapore

Nature, 2007, vol. 450, issue 7167, E2-E4

Abstract: Abstract Replying to: J. T. Bennett et al. Nature 450, doi:10.1038/nature06314 (2007) We presented several lines of evidence indicating that dorso–ventral asymmetry is apparent in zebrafish embryos by cleavage stages1, one of which showed that injection of three different morpholino oligonucleotides targeting three different squint (sqt) sequences cause severe disruption in dorsal structures. We concluded that the dorsal axis is evident by the 4-cell stage, and suggested that maternal Sqt and associated factors may function in zebrafish dorsal-axis formation1. Bennett et al. challenge our results obtained with morpholino oligonucleotides because they do not find a comparable defect in maternal and zygotic sqt mutants2.

Date: 2007
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DOI: 10.1038/nature06315

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