SMRT-mediated repression of an H3K27 demethylase in progression from neural stem cell to neuron

Kristen Jepsen (), Derek Solum, Tianyuan Zhou, Robert J. McEvilly, Hyun-Jung Kim, Christopher K. Glass, Ola Hermanson and Michael G. Rosenfeld
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Kristen Jepsen: Howard Hughes Medical Institute
Derek Solum: Howard Hughes Medical Institute
Tianyuan Zhou: Howard Hughes Medical Institute
Robert J. McEvilly: Howard Hughes Medical Institute
Hyun-Jung Kim: Howard Hughes Medical Institute
Christopher K. Glass: University of California, San Diego, School of Medicine, 9500 Gilman Drive, La Jolla, California 92093, USA
Ola Hermanson: Center of Excellence in Developmental Biology (CEDB/DBRM), Organic Bioelectronics (OBOE), Karolinska Institutet
Michael G. Rosenfeld: Howard Hughes Medical Institute

Nature, 2007, vol. 450, issue 7168, 415-419

Abstract: The SMRT transcriptional co-repressor is shown to have a crucial role in forebrain development and in maintaining neural stem cells, and it represses expression of a histone H3 trimethyl K27 demethylase, which can activate components of the neurogenic programme.

Date: 2007
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DOI: 10.1038/nature06270

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