Molecular basis of RNA-dependent RNA polymerase II activity

Elisabeth Lehmann, Florian Brueckner and Patrick Cramer ()
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Elisabeth Lehmann: Gene Center Munich and Center for integrated Protein Science (CiPSM), Ludwig-Maximilians-Universität München, Feodor-Lynen-Strasse 25, 81377 Munich, Germany
Florian Brueckner: Gene Center Munich and Center for integrated Protein Science (CiPSM), Ludwig-Maximilians-Universität München, Feodor-Lynen-Strasse 25, 81377 Munich, Germany
Patrick Cramer: Gene Center Munich and Center for integrated Protein Science (CiPSM), Ludwig-Maximilians-Universität München, Feodor-Lynen-Strasse 25, 81377 Munich, Germany

Nature, 2007, vol. 450, issue 7168, 445-449

Abstract: New tricks RNA polymerase II, the enzyme responsible for transcription, the first step in gene expression, was thought to use only DNA as a template. But it now emerges that RNA polymerase II can also produce complementary RNA products from an RNA template. This newly discovered activity of a central player in eukaryotic cells is probably involved in gene regulatory mechanisms that are based on small RNA molecules.

Date: 2007
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DOI: 10.1038/nature06290

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