Identification of Tim4 as a phosphatidylserine receptor

Masanori Miyanishi, Kazutoshi Tada, Masato Koike, Yasuo Uchiyama, Toshio Kitamura and Shigekazu Nagata ()
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Masanori Miyanishi: Graduate School of Medicine, Kyoto University, Yoshida, Sakyo-ku, Kyoto 606-8501, Japan
Kazutoshi Tada: Department of Genetics,
Masato Koike: Osaka University Medical School, Osaka 565-0871, Japan
Yasuo Uchiyama: Osaka University Medical School, Osaka 565-0871, Japan
Toshio Kitamura: The Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639, Japan
Shigekazu Nagata: Graduate School of Medicine, Kyoto University, Yoshida, Sakyo-ku, Kyoto 606-8501, Japan

Nature, 2007, vol. 450, issue 7168, 435-439

Abstract: Apoptosis on the menu During programmed cell death in multicellular organisms, a large number of cells are engulfed by macrophages, thus avoiding the release of noxious materials from the dying cells. These 'apoptotic' cells expose phosphatidylserine (PS) on their surface as an 'eat-me' signal. Miyanishi et al. show that the receptors Tim4 and Tim1 are implicated in phagocyte recognition of PS, while Park et al. show that the BAI1 protein is a receptor for PS in mammalian macrophages.

Date: 2007
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DOI: 10.1038/nature06307

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