BAI1 is an engulfment receptor for apoptotic cells upstream of the ELMO/Dock180/Rac module

Daeho Park, Annie-Carole Tosello-Trampont, Michael R. Elliott, Mingjian Lu, Lisa B. Haney, Zhong Ma, Alexander L. Klibanov, James W. Mandell and Kodi S. Ravichandran ()
Additional contact information
Daeho Park: Department of Cell Biology,
Annie-Carole Tosello-Trampont: Carter Immunology Center,
Michael R. Elliott: Carter Immunology Center,
Mingjian Lu: Department of Microbiology,
Lisa B. Haney: Carter Immunology Center,
Zhong Ma: Carter Immunology Center,
Alexander L. Klibanov: Cardiovascular Division and,
James W. Mandell: University of Virginia, Charlottesville, Virginia 22908, USA
Kodi S. Ravichandran: Carter Immunology Center,

Nature, 2007, vol. 450, issue 7168, 430-434

Abstract: Apoptosis on the menu During programmed cell death in multicellular organisms, a large number of cells are engulfed by macrophages, thus avoiding the release of noxious materials from the dying cells. These 'apoptotic' cells expose phosphatidylserine (PS) on their surface as an 'eat-me' signal. Miyanishi et al. show that the receptors Tim4 and Tim1 are implicated in phagocyte recognition of PS, while Park et al. show that the BAI1 protein is a receptor for PS in mammalian macrophages.

Date: 2007
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DOI: 10.1038/nature06329

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