The inhibitory cytokine IL-35 contributes to regulatory T-cell function

Lauren W. Collison, Creg J. Workman, Timothy T. Kuo, Kelli Boyd, Yao Wang, Kate M. Vignali, Richard Cross, David Sehy, Richard S. Blumberg and Dario A. A. Vignali ()
Additional contact information
Lauren W. Collison: Department of Immunology,
Creg J. Workman: Department of Immunology,
Timothy T. Kuo: Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Kelli Boyd: Animal Resources Center, St Jude Children’s Research Hospital, Memphis, Tennessee 38105, USA
Yao Wang: Department of Immunology,
Kate M. Vignali: Department of Immunology,
Richard Cross: Department of Immunology,
David Sehy: eBioscience, San Diego, California 92121, USA
Richard S. Blumberg: Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Dario A. A. Vignali: Department of Immunology,

Nature, 2007, vol. 450, issue 7169, 566-569

Abstract: Regulatory T cells suppress immune function by direct cell to cell contact and secretion of the cytokines IL-10 and TGF-β. In this paper, a novel member of the IL-12 cytokine family that contributes to Treg function is identified.

Date: 2007
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DOI: 10.1038/nature06306

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