A SNARE–adaptor interaction is a new mode of cargo recognition in clathrin-coated vesicles

Sharon E. Miller, Brett M. Collins, Airlie J. McCoy, Margaret S. Robinson () and David J. Owen ()
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Sharon E. Miller: University of Cambridge, CIMR, Wellcome Trust/MRC Building, Hills Road, Cambridge, CB2 0XY, UK
Brett M. Collins: IMB, University of Queensland, Queensland Bioscience Precinct, Building 80, Services Road, St Lucia, Queensland 4075, Australia
Airlie J. McCoy: University of Cambridge, CIMR, Wellcome Trust/MRC Building, Hills Road, Cambridge, CB2 0XY, UK
Margaret S. Robinson: University of Cambridge, CIMR, Wellcome Trust/MRC Building, Hills Road, Cambridge, CB2 0XY, UK
David J. Owen: University of Cambridge, CIMR, Wellcome Trust/MRC Building, Hills Road, Cambridge, CB2 0XY, UK

Nature, 2007, vol. 450, issue 7169, 570-574

Abstract: The crystal structure of a SNARE protein bound to a clathrin adaptor is reported, which reveals that there is highly specific interactions between two folded domains as opposed to the linear peptide motif or folded domains that have been described for other families of cargo proteins. This is the first example of a SNARE association with a clathrin adaptor and describes a novel mechanism by which cargo can be recruited into clathrin coated vesicles.

Date: 2007
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DOI: 10.1038/nature06353

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