Calcineurin sets the bandwidth for discrimination of signals during thymocyte development

Elena M. Gallo, Monte M. Winslow, Kirsten Canté-Barrett, Amy N. Radermacher, Lena Ho, Lisa McGinnis, Brian Iritani, Joel R. Neilson and Gerald R. Crabtree ()
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Elena M. Gallo: Stanford University, Stanford, California 94305, USA
Monte M. Winslow: Stanford University, Stanford, California 94305, USA
Kirsten Canté-Barrett: Stanford University, Stanford, California 94305, USA
Amy N. Radermacher: Stanford University, Stanford, California 94305, USA
Lena Ho: Stanford University, Stanford, California 94305, USA
Lisa McGinnis: Stanford University, Stanford, California 94305, USA
Brian Iritani: School of Medicine, University of Washington, Seattle, Washington 98195, USA
Joel R. Neilson: Stanford University, Stanford, California 94305, USA
Gerald R. Crabtree: Stanford University, Stanford, California 94305, USA

Nature, 2007, vol. 450, issue 7170, 731-735

Abstract: Immature thymic T cells receive signals through the T cell receptor which determine whether they undergo positive or negative selection. Calcineurin/NFAT signalling in preselection thymocytes produces a temporal window with enhanced signalling sensitivity paving the way for positive selection.

Date: 2007
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DOI: 10.1038/nature06305

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