The centromere geometry essential for keeping mitosis error free is controlled by spindle forces

Jadranka Lončarek, Olga Kisurina-Evgenieva, Tatiana Vinogradova, Polla Hergert, Sabrina La Terra, Tarun M. Kapoor () and Alexey Khodjakov ()
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Jadranka Lončarek: Wadsworth Center, Albany, Albany, New York 12201-0509, USA
Olga Kisurina-Evgenieva: Wadsworth Center, Albany, Albany, New York 12201-0509, USA
Tatiana Vinogradova: Wadsworth Center, Albany, Albany, New York 12201-0509, USA
Polla Hergert: Wadsworth Center, Albany, Albany, New York 12201-0509, USA
Sabrina La Terra: Wadsworth Center, Albany, Albany, New York 12201-0509, USA
Tarun M. Kapoor: Laboratory of Chemistry and Cell Biology, The Rockefeller University, New York, New York 10021, USA
Alexey Khodjakov: Wadsworth Center, Albany, Albany, New York 12201-0509, USA

Nature, 2007, vol. 450, issue 7170, 745-749

Abstract: This paper addresses the question of how centromere architecture affects spindle formation, and presents evidence supporting the claim that centromeres are malleable with respect to tangential forces. Once deformed, they remain in this position until they are straightened by external forces applied along microtubules.

Date: 2007
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DOI: 10.1038/nature06344

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