Intracellular bacterial growth is controlled by a kinase network around PKB/AKT1

Coenraad Kuijl, Nigel D. L. Savage, Marije Marsman, Adriaan W. Tuin, Lennert Janssen, David A. Egan, Mirjam Ketema, Rian van den Nieuwendijk, Susan J. F. van den Eeden, Annemieke Geluk, Alex Poot, Gijs van der Marel, Roderick L. Beijersbergen, Hermen Overkleeft, Tom H. M. Ottenhoff and Jacques Neefjes ()
Additional contact information
Coenraad Kuijl: and
Nigel D. L. Savage: Leiden Medical University Centre, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
Marije Marsman: and
Adriaan W. Tuin: Leiden Institute of Chemistry
Lennert Janssen: and
David A. Egan: The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
Mirjam Ketema: and
Rian van den Nieuwendijk: Leiden Institute of Chemistry
Susan J. F. van den Eeden: Leiden Medical University Centre, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
Annemieke Geluk: Leiden Medical University Centre, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
Alex Poot: Leiden Institute of Chemistry
Gijs van der Marel: Leiden Institute of Chemistry
Roderick L. Beijersbergen: The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
Hermen Overkleeft: Leiden Institute of Chemistry
Tom H. M. Ottenhoff: Leiden Medical University Centre, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
Jacques Neefjes: and

Nature, 2007, vol. 450, issue 7170, 725-730

Abstract: An alternative to antibiotics Conventional antibiotics work by inactivating important pathogen functions, and they are therefore susceptible to the development of antibiotic resistance. An alternative approach is to target host factors that support pathogen growth. A possible target for this approach has been identified using a novel RNA interference screen for kinases capable of inhibiting intracellular growth of Salmonella typhimurium and Mycobacterium tuberculosis. The key molecule is AKT1, a kinase previously known as PKB, and extensively studied because of its anti-apoptotic activity and involvement in uncontrolled cancers.

Date: 2007
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DOI: 10.1038/nature06345

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