Interpretation of the sonic hedgehog morphogen gradient by a temporal adaptation mechanism

Eric Dessaud, Lin Lin Yang, Katy Hill, Barny Cox, Fausto Ulloa, Ana Ribeiro, Anita Mynett, Bennett G. Novitch and James Briscoe ()
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Eric Dessaud: Developmental Neurobiology, National Institute for Medical Research Mill Hill
Lin Lin Yang: University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
Katy Hill: Developmental Neurobiology, National Institute for Medical Research Mill Hill
Barny Cox: Developmental Neurobiology, National Institute for Medical Research Mill Hill
Fausto Ulloa: Developmental Neurobiology, National Institute for Medical Research Mill Hill
Ana Ribeiro: Developmental Neurobiology, National Institute for Medical Research Mill Hill
Anita Mynett: Developmental Neurobiology, National Institute for Medical Research Mill Hill
Bennett G. Novitch: University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
James Briscoe: Developmental Neurobiology, National Institute for Medical Research Mill Hill

Nature, 2007, vol. 450, issue 7170, 717-720

Abstract: Understanding morphogen activity is one of the longest standing problems in developmental biology. Both the duration of exposure to the secreted morphogen Sonic hedgehog (Shh) and the concentration of Shh are important in determining the fate of cells in the neural tube and in the limb bud. This paper clarifies the relationship between time and concentration in Shh signalling during patterning of the neural tube.

Date: 2007
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DOI: 10.1038/nature06347

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