Identification of protein pheromones that promote aggressive behaviour

Pablo Chamero, Tobias F. Marton, Darren W. Logan, Kelly Flanagan, Jason R. Cruz, Alan Saghatelian, Benjamin F. Cravatt and Lisa Stowers ()
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Pablo Chamero: Department of Cell Biology,
Tobias F. Marton: Department of Cell Biology,
Darren W. Logan: Department of Cell Biology,
Kelly Flanagan: Department of Cell Biology,
Jason R. Cruz: Department of Cell Biology,
Alan Saghatelian: Harvard University, Cambridge, Massachusetts 02138, USA
Benjamin F. Cravatt: The Scripps Research Institute, La Jolla, California 92030, USA
Lisa Stowers: Department of Cell Biology,

Nature, 2007, vol. 450, issue 7171, 899-902

Abstract: The scent of aggression Pheromones are chemical signals that regulate innate behaviours between members of the same species. In mice, pup suckling, aggression and mating are all influenced by pheromones detected by neurons in the nasal cavity. Now Chamero et al. report the identification of the protein component of the major urinary protein complex as a potential pheromone ligand mediating male–male aggression via the accessory olfactory neural pathway. This work is a significant step towards understanding intraspecific communication in a mammal and characterizing the neuronal circuitry involved in such behaviour.

Date: 2007
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DOI: 10.1038/nature05997

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