The major Vibrio cholerae autoinducer and its role in virulence factor production

Douglas A. Higgins, Megan E. Pomianek, Christina M. Kraml, Ronald K. Taylor, Martin F. Semmelhack and Bonnie L. Bassler ()
Additional contact information
Douglas A. Higgins: Department of Molecular Biology,
Megan E. Pomianek: Department of Chemistry,
Christina M. Kraml: Lotus Separations LLC, Princeton University, Princeton, New Jersey 08544, USA
Ronald K. Taylor: Dartmouth Medical School, Hanover, New Hampshire 03755, USA
Martin F. Semmelhack: Department of Chemistry,
Bonnie L. Bassler: Department of Molecular Biology,

Nature, 2007, vol. 450, issue 7171, 883-886

Abstract: Cholera pathogen disarmed In a process called quorum sensing, certain bacteria can communicate with each other using chemical signalling molecules, allowing them to synchronize gene expression so that they act virtually as multicellular organisms. The cholera pathogen Vibrio cholerae uses quorum sensing to control virulence and to organize the biofilms that contribute to the difficulties of treating the infection. Now the major V. cholerae quorum-sensing signalling molecule, an autoinducer called CAI-1, has been identified and characterized as (S)-3-hydroxytridecan-4-one, a molecule new to biology. Providing CAI-1 to the bacterium terminates the production of factors required for pathogenicity, suggesting a possible new treatment for this major pathogen.

Date: 2007
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DOI: 10.1038/nature06284

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