Adaptive immunity maintains occult cancer in an equilibrium state

Catherine M. Koebel, William Vermi, Jeremy B. Swann, Nadeen Zerafa, Scott J. Rodig, Lloyd J. Old, Mark J. Smyth () and Robert D. Schreiber ()
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Catherine M. Koebel: Washington University School of Medicine, St. Louis, Missouri 63110, USA
William Vermi: Washington University School of Medicine, St. Louis, Missouri 63110, USA
Jeremy B. Swann: Cancer Immunology Program, Sir Donald and Lady Trescowthick Laboratories, Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Australia
Nadeen Zerafa: Cancer Immunology Program, Sir Donald and Lady Trescowthick Laboratories, Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Australia
Scott J. Rodig: Brigham and Women’s Hospital Harvard Medical School, Boston, Massachusetts 02115, USA
Lloyd J. Old: Ludwig Institute for Cancer Research at Memorial Sloan Kettering Cancer Center
Mark J. Smyth: Cancer Immunology Program, Sir Donald and Lady Trescowthick Laboratories, Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Australia
Robert D. Schreiber: Washington University School of Medicine, St. Louis, Missouri 63110, USA

Nature, 2007, vol. 450, issue 7171, 903-907

Abstract: Tumours are occasionally transferred from donor to recipients during organ transplantation. This paper shows in a mouse model that during latency tumours are actively held in check by the adaptive immune system.

Date: 2007
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DOI: 10.1038/nature06309

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