Characterizing the cancer genome in lung adenocarcinoma

Weir, Barbara A.; Woo, Michele S.; Getz, Gad; Perner, Sven; Ding, Li; Beroukhim, Rameen; Lin, William M.; Province, Michael A.; Kraja, Aldi; Johnson, Laura A.; Shah, Kinjal; Sato, Mitsuo; Thomas, Roman K.; Barletta, Justine A.; Borecki, Ingrid B.; Broderick, Stephen; Chang, Andrew C.; Chiang, Derek Y.; Chirieac, Lucian R.; Cho, Jeonghee; Fujii, Yoshitaka; Gazdar, Adi F.; Giordano, Thomas; Greulich, Heidi; Hanna, Megan; Johnson, Bruce E.; Kris, Mark G.; Lash, Alex; Lin, Ling; Lindeman, Neal; Mardis, Elaine R.; McPherson, John D.; Minna, John D.; Morgan, Margaret B.; Nadel, Mark; Orringer, Mark B.; Osborne, John R.; Ozenberger, Brad; Ramos, Alex H.; Robinson, James; Roth, Jack A.; Rusch, Valerie; Sasaki, Hidefumi; Shepherd, Frances; Sougnez, Carrie; Spitz, Margaret R.; Tsao, Ming-Sound; Twomey, David; Verhaak, Roel G. W.; Weinstock, George M.; Wheeler, David A.; Winckler, Wendy; Yoshizawa, Akihiko; Yu, Soyoung; Zakowski, Maureen F.; Zhang, Qunyuan; Beer, David G.; Wistuba, Ignacio I.; Watson, Mark A.; Garraway, Levi A.; Ladanyi, Marc; Travis, William D.; Pao, William; Rubin, Mark A.; Gabriel, Stacey B.; Gibbs, Richard A.; Varmus, Harold E.; Wilson, Richard K.; Lander, Eric S.; Meyerson, Matthew

Characterizing the cancer genome in lung adenocarcinoma

Barbara A. Weir, Michele S. Woo, Gad Getz, Sven Perner, Li Ding, Rameen Beroukhim, William M. Lin, Michael A. Province, Aldi Kraja, Laura A. Johnson, Kinjal Shah, Mitsuo Sato, Roman K. Thomas, Justine A. Barletta, Ingrid B. Borecki, Stephen Broderick, Andrew C. Chang, Derek Y. Chiang, Lucian R. Chirieac, Jeonghee Cho, Yoshitaka Fujii, Adi F. Gazdar, Thomas Giordano, Heidi Greulich, Megan Hanna, Bruce E. Johnson, Mark G. Kris, Alex Lash, Ling Lin, Neal Lindeman, Elaine R. Mardis, John D. McPherson, John D. Minna, Margaret B. Morgan, Mark Nadel, Mark B. Orringer, John R. Osborne, Brad Ozenberger, Alex H. Ramos, James Robinson, Jack A. Roth, Valerie Rusch, Hidefumi Sasaki, Frances Shepherd, Carrie Sougnez, Margaret R. Spitz, Ming-Sound Tsao, David Twomey, Roel G. W. Verhaak, George M. Weinstock, David A. Wheeler, Wendy Winckler, Akihiko Yoshizawa, Soyoung Yu, Maureen F. Zakowski, Qunyuan Zhang, David G. Beer, Ignacio I. Wistuba, Mark A. Watson, Levi A. Garraway, Marc Ladanyi, William D. Travis, William Pao, Mark A. Rubin, Stacey B. Gabriel, Richard A. Gibbs, Harold E. Varmus, Richard K. Wilson, Eric S. Lander and Matthew Meyerson ()
Additional contact information
Barbara A. Weir: Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA
Michele S. Woo: Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA
Gad Getz: Cancer Program, Genetic Analysis Platform, and Genome Biology Program, Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02142, USA
Sven Perner: Brigham and Women’s Hospital, Boston, Massachusetts 02115, USA
Li Ding: Genome Sequencing Center,
Rameen Beroukhim: Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA
William M. Lin: Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA
Michael A. Province: Division of Statistical Genomics and,
Aldi Kraja: Division of Statistical Genomics and,
Laura A. Johnson: Brigham and Women’s Hospital, Boston, Massachusetts 02115, USA
Kinjal Shah: Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA
Mitsuo Sato: University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
Roman K. Thomas: Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA
Justine A. Barletta: Brigham and Women’s Hospital, Boston, Massachusetts 02115, USA
Ingrid B. Borecki: Division of Statistical Genomics and,
Stephen Broderick: Surgery, Pathology, and Computational Biology
Andrew C. Chang: Section of Thoracic Surgery
Derek Y. Chiang: Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA
Lucian R. Chirieac: Brigham and Women’s Hospital, Boston, Massachusetts 02115, USA
Jeonghee Cho: Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA
Yoshitaka Fujii: Nagoya City University Medical School
Adi F. Gazdar: University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
Thomas Giordano: University of Michigan, Ann Arbor, Michigan 48109, USA
Heidi Greulich: Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA
Megan Hanna: Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA
Bruce E. Johnson: Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA
Mark G. Kris: Surgery, Pathology, and Computational Biology
Alex Lash: Surgery, Pathology, and Computational Biology
Ling Lin: Genome Sequencing Center,
Neal Lindeman: Brigham and Women’s Hospital, Boston, Massachusetts 02115, USA
Elaine R. Mardis: Genome Sequencing Center,
John D. McPherson: Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas 77030, USA
John D. Minna: University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
Margaret B. Morgan: Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas 77030, USA
Mark Nadel: Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA
Mark B. Orringer: Section of Thoracic Surgery
John R. Osborne: Genome Sequencing Center,
Brad Ozenberger: National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
Alex H. Ramos: Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA
James Robinson: Cancer Program, Genetic Analysis Platform, and Genome Biology Program, Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02142, USA
Jack A. Roth: Department of Thoracic and Cardiovascular Surgery,
Valerie Rusch: Surgery, Pathology, and Computational Biology
Hidefumi Sasaki: Nagoya City University Medical School
Frances Shepherd: University Health Network and Princess Margaret Hospital
Carrie Sougnez: Cancer Program, Genetic Analysis Platform, and Genome Biology Program, Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02142, USA
Margaret R. Spitz: Department of Epidemiology,
Ming-Sound Tsao: University Health Network and Princess Margaret Hospital
David Twomey: Cancer Program, Genetic Analysis Platform, and Genome Biology Program, Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02142, USA
Roel G. W. Verhaak: Cancer Program, Genetic Analysis Platform, and Genome Biology Program, Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02142, USA
George M. Weinstock: Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas 77030, USA
David A. Wheeler: Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas 77030, USA
Wendy Winckler: Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA
Akihiko Yoshizawa: Surgery, Pathology, and Computational Biology
Soyoung Yu: Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA
Maureen F. Zakowski: Surgery, Pathology, and Computational Biology
Qunyuan Zhang: Division of Statistical Genomics and,
David G. Beer: Section of Thoracic Surgery
Ignacio I. Wistuba: Department of Pathology and,
Mark A. Watson: Washington University in Saint Louis, Saint Louis, Missouri 63130, USA
Levi A. Garraway: Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA
Marc Ladanyi: Surgery, Pathology, and Computational Biology
William D. Travis: Surgery, Pathology, and Computational Biology
William Pao: Surgery, Pathology, and Computational Biology
Mark A. Rubin: Cancer Program, Genetic Analysis Platform, and Genome Biology Program, Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02142, USA
Stacey B. Gabriel: Cancer Program, Genetic Analysis Platform, and Genome Biology Program, Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02142, USA
Richard A. Gibbs: Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas 77030, USA
Harold E. Varmus: Cancer Biology and Genetics Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA
Richard K. Wilson: Genome Sequencing Center,
Eric S. Lander: Cancer Program, Genetic Analysis Platform, and Genome Biology Program, Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02142, USA
Matthew Meyerson: Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA

Nature, 2007, vol. 450, issue 7171, 893-898

Abstract: Oncogene unmasked A wide-ranging overview of genetic alterations in lung adenocarcinomas, published in this issue, takes a new approach to genome analysis. The analysis of 371 tumours revealed 31 recurrent focal events, only six of which were known previously in lung carcinomas. A new candidate oncogene, TITF1, was found to be significant in a large number of lung cancers. This work shows that there are many more important cancer-related genes still undiscovered, and that systematic genomic study can reveal them.

Date: 2007
References: Add references at CitEc
Citations: View citations in EconPapers (1)

Downloads: (external link)
https://www.nature.com/articles/nature06358 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:450:y:2007:i:7171:d:10.1038_nature06358

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature06358

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().