The SRA protein Np95 mediates epigenetic inheritance by recruiting Dnmt1 to methylated DNA

Jafar Sharif, Masahiro Muto, Shin-ichiro Takebayashi, Isao Suetake, Akihiro Iwamatsu, Takaho A. Endo, Jun Shinga, Yoko Mizutani-Koseki, Tetsuro Toyoda, Kunihiro Okamura, Shoji Tajima, Kohzoh Mitsuya, Masaki Okano and Haruhiko Koseki ()
Additional contact information
Jafar Sharif: Tohoku University Biomedical Engineering Research Organization (TUBERO), 2-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan
Masahiro Muto: RIKEN Research Center for Allergy and Immunology,
Shin-ichiro Takebayashi: RIKEN Center for Developmental Biology, 2-2-3 Minatojima-minamimachi, Chuo-ku, Kobe, Hyogo 650-0047, Japan
Isao Suetake: Institute for Protein Research, Osaka University, 3-2 Yamadaoka, Suita, Osaka 565-0871, Japan
Akihiro Iwamatsu: Protein-Research Network, Inc., 1-13-5 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan
Takaho A. Endo: RIKEN Genomic Sciences Center, 1-7-22 Suehiro, Tsurumi-ku, Yokohama 230-0045, Japan
Jun Shinga: RIKEN Research Center for Allergy and Immunology,
Yoko Mizutani-Koseki: RIKEN Research Center for Allergy and Immunology,
Tetsuro Toyoda: RIKEN Genomic Sciences Center, 1-7-22 Suehiro, Tsurumi-ku, Yokohama 230-0045, Japan
Kunihiro Okamura: Tohoku University School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai 980-8574, Japan
Shoji Tajima: Institute for Protein Research, Osaka University, 3-2 Yamadaoka, Suita, Osaka 565-0871, Japan
Kohzoh Mitsuya: Tohoku University Biomedical Engineering Research Organization (TUBERO), 2-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan
Masaki Okano: RIKEN Center for Developmental Biology, 2-2-3 Minatojima-minamimachi, Chuo-ku, Kobe, Hyogo 650-0047, Japan
Haruhiko Koseki: RIKEN Research Center for Allergy and Immunology,

Nature, 2007, vol. 450, issue 7171, 908-912

Abstract: Np95 recruits the DNA methyltransferase Dnmt1 to hemi-methylated DNA at replicating heterochromatic regions. It is required in vivo to maintain DNA methylation and repress transcription of retrotransposons and imprinted genes

Date: 2007
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DOI: 10.1038/nature06397

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