Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A

Sergey Nejentsev, Joanna M. M. Howson (), Neil M. Walker, Jeffrey Szeszko, Sarah F. Field, Helen E. Stevens, Pamela Reynolds, Matthew Hardy, Erna King, Jennifer Masters, John Hulme, Lisa M. Maier, Deborah Smyth, Rebecca Bailey, Jason D. Cooper, Gloria Ribas, R. Duncan Campbell, David G. Clayton and John A. Todd
Additional contact information
Sergey Nejentsev: Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute of Medical Research, University of Cambridge
Joanna M. M. Howson: Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute of Medical Research, University of Cambridge
Neil M. Walker: Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute of Medical Research, University of Cambridge
Jeffrey Szeszko: Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute of Medical Research, University of Cambridge
Sarah F. Field: Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute of Medical Research, University of Cambridge
Helen E. Stevens: Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute of Medical Research, University of Cambridge
Pamela Reynolds: Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute of Medical Research, University of Cambridge
Matthew Hardy: Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute of Medical Research, University of Cambridge
Erna King: Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute of Medical Research, University of Cambridge
Jennifer Masters: Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute of Medical Research, University of Cambridge
John Hulme: Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute of Medical Research, University of Cambridge
Lisa M. Maier: Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute of Medical Research, University of Cambridge
Deborah Smyth: Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute of Medical Research, University of Cambridge
Rebecca Bailey: Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute of Medical Research, University of Cambridge
Jason D. Cooper: Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute of Medical Research, University of Cambridge
Gloria Ribas: MRC Rosalind Franklin Centre for Genomics Research, Hinxton, Cambridge, CB10 1SB, UK
R. Duncan Campbell: MRC Rosalind Franklin Centre for Genomics Research, Hinxton, Cambridge, CB10 1SB, UK
David G. Clayton: Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute of Medical Research, University of Cambridge

Nature, 2007, vol. 450, issue 7171, 887-892

Abstract: Diabetes The MHC complex, occupying a sizeable section of human chromosome 6, is linked to almost all known autoimmune disorders. A new study uses a large data set from the Wellcome Trust Case Control Consortium to focus more closely on the MHC genes linked to a specific disease, childhood diabetes. Two susceptibility genes emerge: HLA-A and HLA-B. The discovery clarifies the aetiology of type 1 diabetes and points to a class of peptides worth studying in the search for vaccination strategies.

Date: 2007
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DOI: 10.1038/nature06406

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