A hierarchy of timescales in protein dynamics is linked to enzyme catalysis

Katherine A. Henzler-Wildman, Ming Lei, Vu Thai, S. Jordan Kerns, Martin Karplus and Dorothee Kern ()
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Katherine A. Henzler-Wildman: Howard Hughes Medical Institute, Brandeis University, Waltham, Massachusetts 02454, USA
Ming Lei: Howard Hughes Medical Institute, Brandeis University, Waltham, Massachusetts 02454, USA
Vu Thai: Howard Hughes Medical Institute, Brandeis University, Waltham, Massachusetts 02454, USA
S. Jordan Kerns: Howard Hughes Medical Institute, Brandeis University, Waltham, Massachusetts 02454, USA
Martin Karplus: Harvard University, Cambridge, Massachusetts 02138, USA
Dorothee Kern: Howard Hughes Medical Institute, Brandeis University, Waltham, Massachusetts 02454, USA

Nature, 2007, vol. 450, issue 7171, 913-916

Abstract: Pico-to-nanosecond timescale atomic fluctuations in hinge regions of adenylate kinase facilitate the large-scale, slower lid motions that produce a catalytically competent state.

Date: 2007
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DOI: 10.1038/nature06407

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