A viral microRNA functions as an orthologue of cellular miR-155

Eva Gottwein, Neelanjan Mukherjee, Christoph Sachse, Corina Frenzel, William H. Majoros, Jen-Tsan A. Chi, Ravi Braich, Muthiah Manoharan, Jürgen Soutschek, Uwe Ohler and Bryan R. Cullen ()
Additional contact information
Eva Gottwein: Department of Molecular Genetics and Microbiology,
Neelanjan Mukherjee: University Program in Genetics and Genomics,
Christoph Sachse: Cenix BioScience GmbH, Tatzberg 47, 01307 Dresden, Germany
Corina Frenzel: Cenix BioScience GmbH, Tatzberg 47, 01307 Dresden, Germany
William H. Majoros: Institute for Genome Sciences and Policy,
Jen-Tsan A. Chi: Department of Molecular Genetics and Microbiology,
Ravi Braich: Alnylam Pharmaceuticals, Inc., 300 3rd Street, Cambridge, Massachusetts 02142, USA
Muthiah Manoharan: Alnylam Pharmaceuticals, Inc., 300 3rd Street, Cambridge, Massachusetts 02142, USA
Jürgen Soutschek: Alnylam Pharmaceuticals, Inc., 300 3rd Street, Cambridge, Massachusetts 02142, USA
Uwe Ohler: Duke University Medical Center, Durham, North Carolina 27710, USA
Bryan R. Cullen: Department of Molecular Genetics and Microbiology,

Nature, 2007, vol. 450, issue 7172, 1096-1099

Abstract: RNA copied Some viral microRNAs are known to bind host cell mRNAs to block translation or induce their degradation. Now a microRNA from the herpes virus associated with Kaposi's sarcoma has been found to mimic the ubiquitous cellular microRNA, miR-155. The viral version of this RNA, which shows significant homology to the real thing, may have evolved to exploit an existing gene regulatory pathway in host B cells.

Date: 2007
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DOI: 10.1038/nature05992

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