Distinct physiological states of Plasmodium falciparum in malaria-infected patients

J. P. Daily, D. Scanfeld, N. Pochet, K. Le Roch, D. Plouffe, M. Kamal, O. Sarr, S. Mboup, O. Ndir, D. Wypij, K. Levasseur, E. Thomas, P. Tamayo, C. Dong, Y. Zhou, E. S. Lander, D. Ndiaye, D. Wirth, E. A. Winzeler, J. P. Mesirov () and A. Regev ()
Additional contact information
J. P. Daily: Department of Immunology and Infectious Disease,
D. Scanfeld: Broad Institute of Massachusetts Institute of Technology and Harvard University, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA
N. Pochet: Broad Institute of Massachusetts Institute of Technology and Harvard University, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA
K. Le Roch: 900 University Avenue, University of California, Riverside, California 92521, USA
D. Plouffe: Genomics Institute of the Novartis Research Foundation, San Diego, California 92121, USA
M. Kamal: Broad Institute of Massachusetts Institute of Technology and Harvard University, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA
O. Sarr: Laboratory of Bacteriology and Virology,
S. Mboup: Laboratory of Bacteriology and Virology,
O. Ndir: Dantec Hospital, Cheikh Anta Diop University, Dakar, BP 5005, Senegal
D. Wypij: Harvard School of Public Health, 665 Huntington Avenue, Boston, Massachusetts 02115, USA
K. Levasseur: Department of Immunology and Infectious Disease,
E. Thomas: Broad Institute of Massachusetts Institute of Technology and Harvard University, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA
P. Tamayo: Broad Institute of Massachusetts Institute of Technology and Harvard University, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA
C. Dong: Department of Immunology and Infectious Disease,
Y. Zhou: Genomics Institute of the Novartis Research Foundation, San Diego, California 92121, USA
E. S. Lander: Broad Institute of Massachusetts Institute of Technology and Harvard University, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA
D. Ndiaye: Dantec Hospital, Cheikh Anta Diop University, Dakar, BP 5005, Senegal
D. Wirth: Department of Immunology and Infectious Disease,
E. A. Winzeler: Genomics Institute of the Novartis Research Foundation, San Diego, California 92121, USA
J. P. Mesirov: Broad Institute of Massachusetts Institute of Technology and Harvard University, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA
A. Regev: Broad Institute of Massachusetts Institute of Technology and Harvard University, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA

Nature, 2007, vol. 450, issue 7172, 1091-1095

Abstract: Triple identity for malaria A major puzzle in understanding malaria is the wide range of clinical conditions seen in infected children — from mild flu-like symptoms to coma and death. A large-scale transcriptional analysis of malaria parasites isolated from human patients has uncovered a possible clue to this variation: Plasmodium falciparum exists in its human host in three different physiological states. These can be described as active growth, a response to starvation, and an environmental stress response. This finding has important implications both for treatment with current drugs and for future drug and vaccine development.

Date: 2007
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DOI: 10.1038/nature06311

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