RAG2 PHD finger couples histone H3 lysine 4 trimethylation with V(D)J recombination

Adam G. W. Matthews, Alex J. Kuo, Santiago Ramón-Maiques, Sunmi Han, Karen S. Champagne, Dmitri Ivanov, Mercedes Gallardo, Dylan Carney, Peggie Cheung, David N. Ciccone, Kay L. Walter, Paul J. Utz, Yang Shi, Tatiana G. Kutateladze, Wei Yang, Or Gozani () and Marjorie A. Oettinger ()
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Adam G. W. Matthews: Harvard Medical School, Boston, Massachusetts 02114, USA
Alex J. Kuo: Stanford University, Stanford, California 94305, USA
Santiago Ramón-Maiques: Laboratory of Molecular Biology, NIDDK, NIH, Bethesda, Maryland 20892, USA
Sunmi Han: Harvard Medical School, Boston, Massachusetts 02114, USA
Karen S. Champagne: University of Colorado Health Sciences Center, Aurora, Colorado 80045, USA
Dmitri Ivanov: Harvard Medical School, Boston, Massachusetts 02115, USA
Mercedes Gallardo: Harvard Medical School, Boston, Massachusetts 02114, USA
Dylan Carney: Stanford University, Stanford, California 94305, USA
Peggie Cheung: Stanford University, Stanford, California 94305, USA
David N. Ciccone: Harvard Medical School, Boston, Massachusetts 02114, USA
Kay L. Walter: Stanford University, Stanford, California 94305, USA
Paul J. Utz: Stanford University School of Medicine, Stanford, California 94305, USA
Yang Shi: Harvard Medical School, Boston, Massachusetts 02115, USA
Tatiana G. Kutateladze: University of Colorado Health Sciences Center, Aurora, Colorado 80045, USA
Wei Yang: Laboratory of Molecular Biology, NIDDK, NIH, Bethesda, Maryland 20892, USA
Or Gozani: Stanford University, Stanford, California 94305, USA
Marjorie A. Oettinger: Harvard Medical School, Boston, Massachusetts 02114, USA

Nature, 2007, vol. 450, issue 7172, 1106-1110

Abstract: RAG2, a component of the V(D)J recombinase, has a plant homeodomain (PHD) domain which specifically recognizes histone H3 trimethylated at lysine 4 (H3K4me3). A crystal structure of the complex is presented, and the interaction between RAG2 and H3K4me3 shown to be important for V(D)J recombination in vivo.

Date: 2007
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DOI: 10.1038/nature06431

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