Dynamic personalities of proteins

Katherine Henzler-Wildman and Dorothee Kern
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Katherine Henzler-Wildman: Howard Hughes Medical Institute, Brandeis University
Dorothee Kern: Howard Hughes Medical Institute, Brandeis University

Nature, 2007, vol. 450, issue 7172, 964-972

Abstract: Abstract Because proteins are central to cellular function, researchers have sought to uncover the secrets of how these complex macromolecules execute such a fascinating variety of functions. Although static structures are known for many proteins, the functions of proteins are governed ultimately by their dynamic character (or 'personality'). The dream is to 'watch' proteins in action in real time at atomic resolution. This requires addition of a fourth dimension, time, to structural biology so that the positions in space and time of all atoms in a protein can be described in detail.

Date: 2007
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DOI: 10.1038/nature06522

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