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The biological impact of mass-spectrometry-based proteomics

Benjamin F. Cravatt, Gabriel M. Simon and John R. Yates
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Benjamin F. Cravatt: The Scripps Research Institute
Gabriel M. Simon: The Scripps Research Institute
John R. Yates: The Scripps Research Institute

Nature, 2007, vol. 450, issue 7172, 991-1000

Abstract: Abstract In the past decade, there have been remarkable advances in proteomic technologies. Mass spectrometry has emerged as the preferred method for in-depth characterization of the protein components of biological systems. Using mass spectrometry, key insights into the composition, regulation and function of molecular complexes and pathways have been gained. From these studies, it is clear that mass-spectrometry-based proteomics is now a powerful 'hypothesis-generating engine' that, when combined with complementary molecular, cellular and pharmacological techniques, provides a framework for translating large data sets into an understanding of complex biological processes.

Date: 2007
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DOI: 10.1038/nature06525

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