Visualizing spatially correlated dynamics that directs RNA conformational transitions

Qi Zhang, Andrew C. Stelzer, Charles K. Fisher and Hashim M. Al-Hashimi ()
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Qi Zhang: University of Michigan, 930 North University Avenue, Ann Arbor, Michigan 48109-1055, USA
Andrew C. Stelzer: University of Michigan, 930 North University Avenue, Ann Arbor, Michigan 48109-1055, USA
Charles K. Fisher: University of Michigan, 930 North University Avenue, Ann Arbor, Michigan 48109-1055, USA
Hashim M. Al-Hashimi: University of Michigan, 930 North University Avenue, Ann Arbor, Michigan 48109-1055, USA

Nature, 2007, vol. 450, issue 7173, 1263-1267

Abstract: This paper reports an NMR approach that enables the three-dimensional movement of two linked RNA helices to be followed for a period up to milliseconds. The two helices move in a highly correlated manner, demonstrating both twisting and bending. Results with different liganded conformations demonstrate that the motions of the unstructured RNA maps out positions within the dynamic envelope described by the bound structures.

Date: 2007
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DOI: 10.1038/nature06389

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