Stochastic gene expression out-of-steady-state in the cyanobacterial circadian clock

Jeffrey R. Chabot, Juan M. Pedraza, Prashant Luitel and Alexander van Oudenaarden ()
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Jeffrey R. Chabot: Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
Juan M. Pedraza: Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
Prashant Luitel: Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
Alexander van Oudenaarden: Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA

Nature, 2007, vol. 450, issue 7173, 1249-1252

Abstract: This paper shows how noisy gene expression causes a bacterial cell to slowly lose track of time, as measured by its circadian clock. The theoretical framework thus introduced breaks the ground for the analysis of noise in other out-of-equilibrium living systems.

Date: 2007
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DOI: 10.1038/nature06395

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