Nanog safeguards pluripotency and mediates germline development

Ian Chambers (), Jose Silva, Douglas Colby, Jennifer Nichols, Bianca Nijmeijer, Morag Robertson, Jan Vrana, Ken Jones, Lars Grotewold and Austin Smith
Additional contact information
Ian Chambers: MRC Centre Development in Stem Cell Biology, Institute for Stem Cell Research, School of Biological Sciences, University of Edinburgh, King’s Buildings, West Mains Road, Edinburgh EH9 3JQ, UK
Jose Silva: Wellcome Trust Centre for Stem Cell Research,
Douglas Colby: MRC Centre Development in Stem Cell Biology, Institute for Stem Cell Research, School of Biological Sciences, University of Edinburgh, King’s Buildings, West Mains Road, Edinburgh EH9 3JQ, UK
Jennifer Nichols: Wellcome Trust Centre for Stem Cell Research,
Bianca Nijmeijer: MRC Centre Development in Stem Cell Biology, Institute for Stem Cell Research, School of Biological Sciences, University of Edinburgh, King’s Buildings, West Mains Road, Edinburgh EH9 3JQ, UK
Morag Robertson: MRC Centre Development in Stem Cell Biology, Institute for Stem Cell Research, School of Biological Sciences, University of Edinburgh, King’s Buildings, West Mains Road, Edinburgh EH9 3JQ, UK
Jan Vrana: MRC Centre Development in Stem Cell Biology, Institute for Stem Cell Research, School of Biological Sciences, University of Edinburgh, King’s Buildings, West Mains Road, Edinburgh EH9 3JQ, UK
Ken Jones: Wellcome Trust Centre for Stem Cell Research,
Lars Grotewold: MRC Centre Development in Stem Cell Biology, Institute for Stem Cell Research, School of Biological Sciences, University of Edinburgh, King’s Buildings, West Mains Road, Edinburgh EH9 3JQ, UK
Austin Smith: Wellcome Trust Centre for Stem Cell Research,

Nature, 2007, vol. 450, issue 7173, 1230-1234

Abstract: Nanog changes tack In 2003 the transcription factor Nanog was identified as a key contributor to the property that makes embryonic stem cells unique: pluripotency. Nanog, named after Tir nan Og, the 'land of the forever-young' of Celtic myth, was thought to be required for stem cells to multiply while retaining the potential to differentiate. New work in mouse embryonic stem cells suggests a rather different picture. In fact Nanog is not essential for maintaining pluripotency; its levels fluctuate, but Nanog appears to stabilize the pluripotent state by resisting or reversing alternative states of gene expression.

Date: 2007
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DOI: 10.1038/nature06403

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