Stem cell treatment of dystrophic dogs

Allan H. Bretag ()
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Allan H. Bretag: Sansom Institute, School of Pharmacy and Medical Sciences, University of South Australia

Nature, 2007, vol. 450, issue 7173, E23-E23

Abstract: Abstract Arising from: M. Sampaolesi et al. Nature 444, 574–579 (2006)10.1038/nature05282 ; Sampaolesi et al. reply Human muscular dystrophies are devastating and incurable inherited diseases. Hopes of progress towards therapy of muscular dystrophies were aroused when Sampaolesi et al.1 reported “extensive recovery of dystrophin expression, normal muscle...function”, and “remarkable clinical amelioration” in golden retriever muscular dystrophy dogs treated with ‘mesoangioblasts’. Here I re-examine their results, showing how their assessments might be flawed and their conclusions overstated. Further studies will be required to evaluate fully the clinical potential of this work.

Date: 2007
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DOI: 10.1038/nature06437

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