TRPC channel activation by extracellular thioredoxin

Shang-Zhong Xu, Piruthivi Sukumar, Fanning Zeng, Jing Li, Amit Jairaman, Anne English, Jacqueline Naylor, Coziana Ciurtin, Yasser Majeed, Carol J. Milligan, Yahya M. Bahnasi, Eman Al-Shawaf, Karen E. Porter, Lin-Hua Jiang, Paul Emery, Asipu Sivaprasadarao and David J. Beech ()
Additional contact information
Shang-Zhong Xu: Institute of Membrane and Systems Biology, Garstang Building, Faculty of Biological Sciences, and,
Piruthivi Sukumar: Institute of Membrane and Systems Biology, Garstang Building, Faculty of Biological Sciences, and,
Fanning Zeng: Institute of Membrane and Systems Biology, Garstang Building, Faculty of Biological Sciences, and,
Jing Li: Institute of Membrane and Systems Biology, Garstang Building, Faculty of Biological Sciences, and,
Amit Jairaman: Institute of Membrane and Systems Biology, Garstang Building, Faculty of Biological Sciences, and,
Anne English: Academic Unit of Musculoskeletal Disease, Chapel Allerton Hospital
Jacqueline Naylor: Institute of Membrane and Systems Biology, Garstang Building, Faculty of Biological Sciences, and,
Coziana Ciurtin: Institute of Membrane and Systems Biology, Garstang Building, Faculty of Biological Sciences, and,
Yasser Majeed: Institute of Membrane and Systems Biology, Garstang Building, Faculty of Biological Sciences, and,
Carol J. Milligan: Institute of Membrane and Systems Biology, Garstang Building, Faculty of Biological Sciences, and,
Yahya M. Bahnasi: Institute of Membrane and Systems Biology, Garstang Building, Faculty of Biological Sciences, and,
Eman Al-Shawaf: Institute of Membrane and Systems Biology, Garstang Building, Faculty of Biological Sciences, and,
Karen E. Porter: School of Medicine, University of Leeds, Leeds LS2 9JT, UK
Lin-Hua Jiang: Institute of Membrane and Systems Biology, Garstang Building, Faculty of Biological Sciences, and,
Paul Emery: Academic Unit of Musculoskeletal Disease, Chapel Allerton Hospital
Asipu Sivaprasadarao: Institute of Membrane and Systems Biology, Garstang Building, Faculty of Biological Sciences, and,
David J. Beech: Institute of Membrane and Systems Biology, Garstang Building, Faculty of Biological Sciences, and,

Nature, 2008, vol. 451, issue 7174, 69-72

Abstract: Reducing agents can activate different members of the transient receptor potential (TRP) superfamily of ion channels (TRPC1 and TRPC5) by breaking a disulphide bridge in the extracellular loop adjacent to the ion permation pore. A high concentration of the endogenous reducing agent, thioredoxin, is present in rheumatoid arthritis and may reduce secretion of matrix metalloproteinases by its inhibition of TRPC1 and TRPC5.

Date: 2008
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DOI: 10.1038/nature06414

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