Structure of the sulphiredoxin–peroxiredoxin complex reveals an essential repair embrace

Thomas J. Jönsson, Lynnette C. Johnson and W. Todd Lowther ()
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Thomas J. Jönsson: Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, North Carolina 27157, USA
Lynnette C. Johnson: Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, North Carolina 27157, USA
W. Todd Lowther: Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, North Carolina 27157, USA

Nature, 2008, vol. 451, issue 7174, 98-101

Abstract: The X-ray crystal structure of peroxiredoxin bound to sulphiredoxin is solved. In this structure of the co-complex, the carboxy terminus of peroxiredoxin is completely unfolded, and it is 'packed' onto the backside of sulphiredoxin, away from the sulphiredoxin active site. Binding studies and activity analyses of site-directed mutants at this interface show that the interaction is required for repair to occur.

Date: 2008
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DOI: 10.1038/nature06415

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