Poly(ADP-ribose)-binding zinc finger motifs in DNA repair/checkpoint proteins

Ivan Ahel, Dragana Ahel, Takahiro Matsusaka, Allison J. Clark, Jonathon Pines, Simon J. Boulton () and Stephen C. West ()
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Ivan Ahel: Genetic Recombination and,
Dragana Ahel: DNA Damage Response Laboratories, Cancer Research UK London Research Institute, Clare Hall Laboratories, South Mimms, Herts EN6 3LD, UK
Takahiro Matsusaka: Wellcome Trust/Cancer Research UK Gurdon Institute, Tennis Court Road, Cambridge CB2 1QR, UK
Allison J. Clark: DNA Damage Response Laboratories, Cancer Research UK London Research Institute, Clare Hall Laboratories, South Mimms, Herts EN6 3LD, UK
Jonathon Pines: Wellcome Trust/Cancer Research UK Gurdon Institute, Tennis Court Road, Cambridge CB2 1QR, UK
Simon J. Boulton: DNA Damage Response Laboratories, Cancer Research UK London Research Institute, Clare Hall Laboratories, South Mimms, Herts EN6 3LD, UK
Stephen C. West: Genetic Recombination and,

Nature, 2008, vol. 451, issue 7174, 81-85

Abstract: A novel poly(ADP-ribose)-binding zinc finger (PBZ) motif is identified. This motif is found in several eukaryotic checkpoint and DNA repair proteins, such as CHFR and APLF. Mutations in the PBZ of CHFR affect its function in checkpoint regulation, suggesting that both the poly (ADP-ribosyl)ation of proteins, and the interaction of this modification with other factors, is important for the DNA damage response.

Date: 2008
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DOI: 10.1038/nature06420

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