Trisomy represses ApcMin -mediated tumours in mouse models of Down’s syndrome

Thomas E. Sussan, Annan Yang, Fu Li, Michael C. Ostrowski and Roger H. Reeves ()
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Thomas E. Sussan: The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Annan Yang: The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Fu Li: Ohio State University, Columbus, Ohio 43210, USA
Michael C. Ostrowski: Ohio State University, Columbus, Ohio 43210, USA
Roger H. Reeves: The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA

Nature, 2008, vol. 451, issue 7174, 73-75

Abstract: Down's syndrome cancers Some epidemiological studies have suggested that individuals with Down's syndrome (who carry three copies of chromosome 21, known as trisomy 21) show a reduced incidence of solid tumours. Other studies failed to confirm this. Experiments in the Ts65Dn mouse model of Down's syndrome, trisomic for about 100 genes, may have resolved these contradictory findings. They reveal that trisomy for a subset of mouse equivalents of chromosome 21 genes reduces the incidence of some intestinal tumours, yet the presence of one copy of the same genes increases the number of tumours. The dosage-dependent effect is attributed to the Ets2 transcription factor. So Ets2, known until now as an oncogene, is also a tumour repressor, and is a potential target for anticancer prophylaxis.

Date: 2008
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DOI: 10.1038/nature06446

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