Distinct domains of tRNA synthetase recognize the same base pair

Kirk Beebe, Marissa Mock, Eve Merriman and Paul Schimmel ()
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Kirk Beebe: The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
Marissa Mock: The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
Eve Merriman: The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
Paul Schimmel: The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA

Nature, 2008, vol. 451, issue 7174, 90-93

Abstract: Aminoacyl-tRNA synthetases attach amino acids to tRNAs. Occasionally, an incorrect amino acid will attached to the wrong tRNA, and this must be reversed, or edited, to prevent the wrong amino acid from being incorporated into protein. This paper shows that the same base-pair in the tRNA that is important for the aminoacyl reaction is also important for editing, and that surprisingly, the proofreading site is in a different domain of the protein.

Date: 2008
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DOI: 10.1038/nature06454

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