Epigenetic silencing of tumour suppressor gene p15 by its antisense RNA

Wenqiang Yu, David Gius, Patrick Onyango, Kristi Muldoon-Jacobs, Judith Karp, Andrew P. Feinberg () and Hengmi Cui ()
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Wenqiang Yu: Johns Hopkins University School of Medicine, 720 Rutland Avenue, Baltimore, Maryland 21205, USA
David Gius: Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Building 10, 3B43, 9000 Rockville Pike, Bethesda, Maryland 20892, USA
Patrick Onyango: Johns Hopkins University School of Medicine, 720 Rutland Avenue, Baltimore, Maryland 21205, USA
Kristi Muldoon-Jacobs: Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Building 10, 3B43, 9000 Rockville Pike, Bethesda, Maryland 20892, USA
Judith Karp: Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, 401 North Broadway, Baltimore, Maryland 21231, USA
Andrew P. Feinberg: Johns Hopkins University School of Medicine, 720 Rutland Avenue, Baltimore, Maryland 21205, USA
Hengmi Cui: Johns Hopkins University School of Medicine, 720 Rutland Avenue, Baltimore, Maryland 21205, USA

Nature, 2008, vol. 451, issue 7175, 202-206

Abstract: Widespread sense-antisense transcripts have been identified in mammalian cells. Many tumour suppressor genes have nearby antisense RNAs, and an antisense RNA to the cyclin-dependent kinase inhibitor p15 can silence the p15 gene by inducing heterochromatin formation.

Date: 2008
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DOI: 10.1038/nature06468

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