Ultra-fine frequency tuning revealed in single neurons of human auditory cortex

Y. Bitterman, R. Mukamel, R. Malach, I. Fried () and I. Nelken ()
Additional contact information
Y. Bitterman: Life Science Institute
R. Mukamel: Ahmanson-Lovelace Brain Mapping Center, David Geffen School of Medicine,
R. Malach: Weizmann Institute of Science
I. Fried: David Geffen School of Medicine and Semel Institute for Neuroscience and Human Behaviour, University of California Los Angeles (UCLA), Los Angeles, California 90095, USA
I. Nelken: Life Science Institute

Nature, 2008, vol. 451, issue 7175, 197-201

Abstract: Abstract Just-noticeable differences of physical parameters are often limited by the resolution of the peripheral sensory apparatus. Thus, two-point discrimination in vision is limited by the size of individual photoreceptors. Frequency selectivity is a basic property of neurons in the mammalian auditory pathway1,2. However, just-noticeable differences of frequency are substantially smaller than the bandwidth of the peripheral sensors3. Here we report that frequency tuning in single neurons recorded from human auditory cortex in response to random-chord stimuli is far narrower than that typically described in any other mammalian species (besides bats), and substantially exceeds that attributed to the human auditory periphery. Interestingly, simple spectral filter models failed to predict the neuronal responses to natural stimuli, including speech and music. Thus, natural sounds engage additional processing mechanisms beyond the exquisite frequency tuning probed by the random-chord stimuli.

Date: 2008
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DOI: 10.1038/nature06476

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