The bacterial enzyme RppH triggers messenger RNA degradation by 5′ pyrophosphate removal

Atilio Deana, Helena Celesnik and Joel G. Belasco ()
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Atilio Deana: Kimmel Center for Biology and Medicine at the Skirball Institute, New York University School of Medicine, New York, New York 10016, USA
Helena Celesnik: Kimmel Center for Biology and Medicine at the Skirball Institute, New York University School of Medicine, New York, New York 10016, USA
Joel G. Belasco: Kimmel Center for Biology and Medicine at the Skirball Institute, New York University School of Medicine, New York, New York 10016, USA

Nature, 2008, vol. 451, issue 7176, 355-358

Abstract: Degradation of bacterial mRNAs involves internal cleavage events, but internal cleavage is prevented until the 5' triphosphate of the mRNA is converted to a monophosphate. However, the identity of this pyrophosphatase was unknown. This work shows that the product of the NudH gene (now called RppH) possesses this activity and accelerates mRNA degradation in vivo. This enzyme is a member of the Nudix family of pyrophosphohydrolases.

Date: 2008
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DOI: 10.1038/nature06475

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