Listeriolysin O allows Listeria monocytogenes replication in macrophage vacuoles

Cheryl L. Birmingham, Veronica Canadien, Natalia A. Kaniuk, Benjamin E. Steinberg, Darren E. Higgins and John H. Brumell ()
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Cheryl L. Birmingham: Cell Biology Program, Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada
Veronica Canadien: Cell Biology Program, Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada
Natalia A. Kaniuk: Cell Biology Program, Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada
Benjamin E. Steinberg: Cell Biology Program, Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada
Darren E. Higgins: Harvard Medical School, Boston, Massachusetts 02115-6092, USA
John H. Brumell: Cell Biology Program, Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada

Nature, 2008, vol. 451, issue 7176, 350-354

Abstract: Listeriosis: trouble in store The bacterial pathogen Listeria monocytogenes is a common a cause of infection in immunocompromised individuals and in pregnancy. It multiplies rapidly in the cytosol of infected cells, but was recently found in intracellular vacuoles in a mouse model of the disease. A closer study of these vacuoles in mice during persistent listeriosis reveals them as sites of comparably slow bacterial replication which may promote bacterial survival in the face of the host immune response.

Date: 2008
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DOI: 10.1038/nature06479

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