Identification of cells initiating human melanomas

Tobias Schatton, George F. Murphy, Natasha Y. Frank, Kazuhiro Yamaura, Ana Maria Waaga-Gasser, Martin Gasser, Qian Zhan, Stefan Jordan, Lyn M. Duncan, Carsten Weishaupt, Robert C. Fuhlbrigge, Thomas S. Kupper, Mohamed H. Sayegh and Markus H. Frank ()
Additional contact information
Tobias Schatton: Transplantation Research Center, Children’s Hospital Boston and Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
George F. Murphy: Department of Pathology and,
Natasha Y. Frank: Transplantation Research Center, Children’s Hospital Boston and Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Kazuhiro Yamaura: Transplantation Research Center, Children’s Hospital Boston and Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Ana Maria Waaga-Gasser: University of Würzburg Medical School
Martin Gasser: University of Würzburg Medical School
Qian Zhan: Department of Pathology and,
Stefan Jordan: Transplantation Research Center, Children’s Hospital Boston and Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Lyn M. Duncan: Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
Carsten Weishaupt: Harvard Skin Disease Research Center, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA
Robert C. Fuhlbrigge: Harvard Skin Disease Research Center, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA
Thomas S. Kupper: Harvard Skin Disease Research Center, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA
Mohamed H. Sayegh: Transplantation Research Center, Children’s Hospital Boston and Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Markus H. Frank: Transplantation Research Center, Children’s Hospital Boston and Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA

Nature, 2008, vol. 451, issue 7176, 345-349

Abstract: Melanoma stem cells Cancer stem cells have been isolated from a number of human tumours. The latest example is a subpopulation of human malignant melanoma initiating cells, identified by their expression of the chemoresistance mediator ABCB5. The size of the ABCB5+ subpopulations correlates with clinical disease progression in patients with melanomas, and preliminary evidence also suggests that these melanoma stem cells can be specifically targeted with antibodies against ABCB5. This offers a potential therapeutic strategy against melanomas, and the study of cells of this type could help answer important questions in cancer biology. The hybrid melanoma cell shown on the cover, depicted as a merged, computer-enhanced fluorescent microscopy image, arose in vivo in a human tumour xenograft through fusion of an ABCB5+ melanoma stem cell with a more differentiated, ABCB5− tumour cell. Nuclei are marked by genetically encoded red (DsRed) and green (EYFP) fluorescent labels, respectively.

Date: 2008
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DOI: 10.1038/nature06489

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