Identification of RPS14 as a 5q- syndrome gene by RNA interference screen
Benjamin L. Ebert,
Jennifer Pretz,
Jocelyn Bosco,
Cindy Y. Chang,
Pablo Tamayo,
Naomi Galili,
Azra Raza,
David E. Root,
Eyal Attar,
Steven R. Ellis and
Todd R. Golub ()
Additional contact information
Benjamin L. Ebert: Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA
Jennifer Pretz: Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA
Jocelyn Bosco: Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA
Cindy Y. Chang: Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA
Pablo Tamayo: Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA
Naomi Galili: University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
Azra Raza: University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
David E. Root: Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA
Eyal Attar: Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Steven R. Ellis: University of Louisville
Todd R. Golub: Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA
Nature, 2008, vol. 451, issue 7176, 335-339
Abstract:
Deletions on chromososme 5q are associated with myelodysplastic lesions. The genes responsible have largely remained elusive. But use of an RNA interference-based approach that can identify haploinsufficient tumour suppressor genes identifies RPS14, which regulates ribosomal RNA processing as a candidate tumour suppressor gene responsible for this so-called 5q− syndrome.
Date: 2008
References: Add references at CitEc
Citations: View citations in EconPapers (2)
Downloads: (external link)
https://www.nature.com/articles/nature06494 Abstract (text/html)
Access to the full text of the articles in this series is restricted.
Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.
Export reference: BibTeX
RIS (EndNote, ProCite, RefMan)
HTML/Text
Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:451:y:2008:i:7176:d:10.1038_nature06494
Ordering information: This journal article can be ordered from
https://www.nature.com/
DOI: 10.1038/nature06494
Access Statistics for this article
Nature is currently edited by Magdalena Skipper
More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().