Identification of RPS14 as a 5q- syndrome gene by RNA interference screen

Benjamin L. Ebert, Jennifer Pretz, Jocelyn Bosco, Cindy Y. Chang, Pablo Tamayo, Naomi Galili, Azra Raza, David E. Root, Eyal Attar, Steven R. Ellis and Todd R. Golub ()
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Benjamin L. Ebert: Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA
Jennifer Pretz: Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA
Jocelyn Bosco: Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA
Cindy Y. Chang: Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA
Pablo Tamayo: Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA
Naomi Galili: University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
Azra Raza: University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
David E. Root: Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA
Eyal Attar: Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Steven R. Ellis: University of Louisville
Todd R. Golub: Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA

Nature, 2008, vol. 451, issue 7176, 335-339

Abstract: Deletions on chromososme 5q are associated with myelodysplastic lesions. The genes responsible have largely remained elusive. But use of an RNA interference-based approach that can identify haploinsufficient tumour suppressor genes identifies RPS14, which regulates ribosomal RNA processing as a candidate tumour suppressor gene responsible for this so-called 5q− syndrome.

Date: 2008
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DOI: 10.1038/nature06494

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