Histone H2AX-dependent GABAA receptor regulation of stem cell proliferation

Michael Andäng, Jens Hjerling-Leffler, Annalena Moliner, T. Kalle Lundgren, Gonçalo Castelo-Branco, Evanthia Nanou, Ester Pozas, Vitezslav Bryja, Sophie Halliez, Hiroshi Nishimaru, Johannes Wilbertz, Ernest Arenas, Martin Koltzenburg, Patrick Charnay, Abdeljabbar El Manira, Carlos F. Ibañez and Patrik Ernfors ()
Additional contact information
Michael Andäng: Division of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics,
Jens Hjerling-Leffler: Division of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics,
Annalena Moliner: Department of Neuroscience,
T. Kalle Lundgren: Division of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics,
Gonçalo Castelo-Branco: Laboratory of Molecular Neurodevelopment
Evanthia Nanou: Department of Neuroscience,
Ester Pozas: Division of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics,
Vitezslav Bryja: Division of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics,
Sophie Halliez: INSERM, U 784, École Normale Supérieure, 75230 Paris Cedex 05, France
Hiroshi Nishimaru: Department of Neuroscience,
Johannes Wilbertz: Karolinska Institutet, 171 77 Stockholm, Sweden
Ernest Arenas: Division of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics,
Martin Koltzenburg: Neural Plasticity Unit, Institute of Child Health, University College London
Patrick Charnay: INSERM, U 784, École Normale Supérieure, 75230 Paris Cedex 05, France
Abdeljabbar El Manira: Department of Neuroscience,
Carlos F. Ibañez: Department of Neuroscience,
Patrik Ernfors: Division of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics,

Nature, 2008, vol. 451, issue 7177, 460-464

Abstract: Stem cell renewal Stem cell self-renewal involves the maintenance of pluripotency under continued proliferation. Proliferation of embryonic stem cells was thought to be constitutive and not to be regulated, because the normal cell cycle regulatory mechanism is not active in these cells. Now Andäng et al. present evidence for a fundamentally new mechanism of cell cycle regulation operating in embryonic stem cells and in other tissue-specific stem cell types. In it, endogenous GABA receptor signalling controls cell proliferation via a mechanism that involves cell cycle proteins previously associated with the cellular DNA damage checkpoint pathway.

Date: 2008
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DOI: 10.1038/nature06488

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