Neurite arborization and mosaic spacing in the mouse retina require DSCAM

Peter G. Fuerst, Amane Koizumi, Richard H. Masland and Robert W. Burgess ()
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Peter G. Fuerst: The Jackson Laboratory, Bar Harbor, Maine 04609, USA
Amane Koizumi: Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Richard H. Masland: Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Robert W. Burgess: The Jackson Laboratory, Bar Harbor, Maine 04609, USA

Nature, 2008, vol. 451, issue 7177, 470-474

Abstract: Making connections Downs syndrome cell adhesion molecules (Dscams) are adhesion molecules of the immunoglolulin superfamily. Drosophila Dscams have been implicated in the organization of neural connectivity, but little is known about the functions of the closely related molecules in vertebrates. Masahito Yamagata and Joshua Sanes now demonstrate a role for Dscam and DscamL in patterning of lamina-specific connections in the chick retina. Two other adhesion molecules, called Sidekick-1 and Sidekick-2, act in a similar way. These molecules are widely distributed in the nervous system and may be part of an 'adhesive code' that patterns neural connections in the brain. Further evidence for the importance of Dscams in vertebrate neural patterning comes from Fuerst et al., who identify a role for DSCAM in establishing neural circuits in the retina of mice.

Date: 2008
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DOI: 10.1038/nature06514

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