Negative regulation of the deacetylase SIRT1 by DBC1

Wenhui Zhao, Jan-Philipp Kruse, Yi Tang, Sung Yun Jung, Jun Qin and Wei Gu ()
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Wenhui Zhao: Institute for Cancer Genetics, Columbia University, 1130 St Nicholas Avenue, New York, New York 10032, USA
Jan-Philipp Kruse: Institute for Cancer Genetics, Columbia University, 1130 St Nicholas Avenue, New York, New York 10032, USA
Yi Tang: Institute for Cancer Genetics, Columbia University, 1130 St Nicholas Avenue, New York, New York 10032, USA
Sung Yun Jung: Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
Jun Qin: Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
Wei Gu: Institute for Cancer Genetics, Columbia University, 1130 St Nicholas Avenue, New York, New York 10032, USA

Nature, 2008, vol. 451, issue 7178, 587-590

Abstract: Linking ageing and cancer The deacetylase SIRT1, the mammalian version of the Sir2 protein that plays a critical role in determining lifespan in yeast, has been implicated in various cellular functions and possibly in tumorigenesis and ageing. The factors regulating SIRT1 are not well known but two groups now report that the tumour suppressor DBC1 is a negative regulator of SIRT1. By inhibiting SIRT1, DBC1 promotes increased acetylation of the tumour suppressor p53 and p53-mediated apoptosis in human cells.

Date: 2008
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DOI: 10.1038/nature06515

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