Lethargus is a Caenorhabditis elegans sleep-like state

David M. Raizen (), John E. Zimmerman, Matthew H. Maycock, Uyen D. Ta, Young-jai You, Meera V. Sundaram and Allan I. Pack
Additional contact information
David M. Raizen: Center for Sleep and Respiratory Neurobiology,
John E. Zimmerman: Center for Sleep and Respiratory Neurobiology,
Matthew H. Maycock: Center for Sleep and Respiratory Neurobiology,
Uyen D. Ta: Center for Sleep and Respiratory Neurobiology,
Young-jai You: University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, Texas 75390-9148, USA
Meera V. Sundaram: Department of Genetics,
Allan I. Pack: Center for Sleep and Respiratory Neurobiology,

Nature, 2008, vol. 451, issue 7178, 569-572

Abstract: Sleeping with the worms Sleep research enters uncharted territory with the discovery of a sleep-like state in the nematode Caenorhabditis elegans. Sleep is vital in most animals but why this is so is largely unknown. The newly discovered quiescent behavioural state in C. elegans, called lethargus, displays many similarities with sleep as defined in mammals and, more recently, in Drosophila. Lethargus is regulated by a cyclic GMP signalling pathway, the first time this mechanism has been linked to sleep but probably not the last, since a similar pathway is conserved in Drosophila.

Date: 2008
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DOI: 10.1038/nature06535

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