Drosophila Pgc protein inhibits P-TEFb recruitment to chromatin in primordial germ cells

Kazuko Hanyu-Nakamura, Hiroko Sonobe-Nojima, Akie Tanigawa, Paul Lasko and Akira Nakamura ()
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Kazuko Hanyu-Nakamura: Laboratory for Germline Development, RIKEN Center for Developmental Biology, Kobe, Hyogo 650-0047, Japan
Hiroko Sonobe-Nojima: Laboratory for Germline Development, RIKEN Center for Developmental Biology, Kobe, Hyogo 650-0047, Japan
Akie Tanigawa: Laboratory for Germline Development, RIKEN Center for Developmental Biology, Kobe, Hyogo 650-0047, Japan
Paul Lasko: McGill University, Montreal, Quebec H3A 1B1, Canada
Akira Nakamura: Laboratory for Germline Development, RIKEN Center for Developmental Biology, Kobe, Hyogo 650-0047, Japan

Nature, 2008, vol. 451, issue 7179, 730-733

Abstract: The gene polar granule component (pgc) has been implicated in the global repression of transcription that occurs in Drosophila germline progenitors and was thought to act as a non-coding RNA. This paper shows that pgc encodes a small protein that represses transcription by preventing recruitment of the elongation factor P-TEFb.

Date: 2008
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DOI: 10.1038/nature06498

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